• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh), Jason Tam (Brandon), Toni Trucks (Patricia Rivers), Stephanie Roth Haberle (Sienna Rowe)
• And: John Carroll Lynch (Will)
• Co-Starring: Clem Cheung (Calvin), William Zielinski (Donald White), Lauren Courtney-Norman (Mrs. White), Kim Fairbanks (Nurse #1), Brendan McHale (Cole Flynn), Mary Jane Myers (Secretary), Eoin O'Shea (Dennis Rowe), Sartaj Phanda (Cab Driver), Hayden Saunier (Floor Nurse), Timothy Wright (Nurse #2)
• Written By: David Schulner
• Directed By: Michael Mayer

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern), Jurnee Smollett-Bell (), Peter Scanavino (Kyle Corrigan)
• Co-Starring: Tony Baris (Church), Cecelia Birt (Nurse Blanca), Laura Chaneski (Kaitlyn), Michael Connolly (Officer Wally Ludlow), Clare Foley (Ruby Taylor), Paul Hickert (Douchey Businessman), Brian Hutchison (Frank Taylor), Royce Johnson (Dr. Mark Gower), Sue Jean Kim (Sue Jean), Brendan McHale (Cole Flynn), Brooke Stacy Mills (Brooke), Sejal Shah (Tejal), Lianda Swain (Hot Steward), Erika Woods (Amanda Marsh)
• Written By: Lisa Zwerling
• Directed By: Jeffrey Reiner

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern), Morgan Spector (Roman)
• Co-Starring: Kate Boyer (Stripper), Brendan Burke (Thug), Janice Bynum (Nurse), Onika Day (Day Shift Stripper), Matt Dellapina (Todd), Stephen Hill (Thug #2), Marvin Johnson (Uniformed Police Officer), Sue Jean Kim (Sue Jean), Michell Nagy (Waitress), Brendan McHale (Cole Flynn), Sejal Shah (Tejal), Lenny Steinline (Police Detective)
• Written By: David Schulner
• Directed By: Jeffrey Reiner

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Jurnee Smollett-Bell (Abby Young)
• And: Jeremy Davidson (Robert)
• Co-Starring:
• Written By: Eric Charmelo & Nicole Snyder
• Directed By: Michael Waxman

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern), Lucy Walters (Bethany Mitchell), Jurnee Smollett-Bell (Abby Young)
• And: Jeremy Davidson (Robert)
• Co-Starring:
• Written By: Lauren Schmidt Hissrich
• Directed By: John Behring

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern)
• And: Jeremy Davidson (Robert)
• Co-Starring:
• Written By: Diana Son
• Directed By: Michael Waxman

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Co-Starring:
• Written By: Tracy Bellomo
• Directed By: Kate Woods

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Jason Tam (Dr. Brandon Kimura)
• And: Jeremy Davidson (Dr. Robert Harris)
• Co-Starring: Cecelia Birt (Nurse Bianca), Michael Braun (Bill Campion), Marisa Brown (Waitress #2), Charlie Corrado (Cabbie), Joilet Harris (Waitress #1), Lee Fuller (Doorman), Natalie Jason (Scrub Nurse), Brendan McHale (Cole Flynn), Accalia Quintana (Chloe Campion), Sejal Shah (Tejal), Raushanah Simmons (Yvonne), Samantha Soule (Dana Campion)
• Written By: Deirdre Mangan
• Directed By: Jeffrey Reiner

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern), Toni Trucks (Dr. Patricia Rivers)
• And: Jeremy Davidson (Dr. Robert Harris)
• Co-Starring: Cecelia Birt (Nurse Bianca), K.C. Clyde (Mike), Danielle Duboise (Hospital Volunteer), Kim Fairbanks (Nurse Skyler), Luke Forbes (Chuck), Brendan McHale (Cole Flynn), Sejal Shah (Tejal), Kristina Teschner (Connie), Brandon Young (Doctor)
• Written By: Tracy Scott Wilson
• Directed By: Colin Bucksey

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Priscilla Lopez (Mrs. Marcado), Patrick Carroll (Ozone)
• And: Jeremy Davidson (Dr. Robert Harris)
• Co-Starring: Danielle Herbert (ER Nurse), Brendan McHale (Cole Flynn), Karina Ortiz (Mercedes Marcado), Howard Pinhasik (Dr. Foster), Rocio Sanchez (Paola Marcado), Kristina Teschner (Connie), Michelle Vawer (Destiny), Vic Victorson (Construction Worker)
• Written By: Aaron Ginsburg & Wade McIntyre
• Directed By: Aaron Lipstadt

• Special Guest Star: Lin-Manuel Miranda (Ruben Marcado)
• Guest Starring: Samm Levine (Josh Stern), Jason Tam (Brandon), Kelly Karbacz (Lieutenant Tracey McCoy), Toni Trucks (Dr. Patricia Rivers)
• And: James Cromwell (Dr. Phillip Charmelo)
• Co-Starring: Rich Alliger (Old Man), Chris Bresky (Barista), Rebeka Choudhury (Young's Assistant), Shayne Coleman (May McCoy), Roman Maleno (Roman), Julie Mun (Stewardess), Aphrodite Nikolovski (Nurse), Sejal Shah (Tejal), Ava Szymanski (Rachel McCoy), Kristina Teschner (Connie), Nicolas Torrens (Kevin McCoy), Karen Vicks (TCMH Clerk), John Wooten (TSA Guard)
• Written By: Zev Borow
• Directed By: Omar Madha

• Guest Starring: Samm Levine (Josh Stern), Jason Tam (Brandon), Liz Stauber (Jason's Mother)
• And: James Cromwell (Dr. Phillip Charmelo)
• Co-Starring:
• Written By: David Foster
• Directed By: Nick Gomez

• Guest Starring: Samm Levine (Josh Stern), Liz Stauber (Jason's Mother)
• And: James Cromwell (Dr. Phillip Charmelo)
• Co-Starring: Cecelia Birt (Nurse Bianca), Joanna Carden (Nurse), John Cromwell (Young Charmelo), Rebeka Choudhury (Young's Assistant), Donna Fisher (Code Nurse), Russell G. Jones (Lars), Suzanne Inman (Older Woman), Clark Jackson (Detective Sam Carson), Atif Lanier (Hospital Security), Dan McGlaughlin (Scrub Nurse), Robert McKay (Fire Chief Wallace), Parker Townsend (Young Ian), Peyton Townsend (Young Jason), Ellis Walding (Guard), Nikki E. Walker (Joanne)
• Teleplay By: David Foster & David Schulner
• Story By: Zev Borow & Lauren Schmidt Hissrich
• Directed By: John Behring