• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• Guest Starring: Bill Irwin (Ron Vinetz), Liam Aiken (Milo), Afton Williamson (Autumn), James McCaffrey (Milt Sandreski), Mary McCann (Jill Sandreski), Susie Abromeit (Lacey Sandreski), Necar Zadegan (Madeline Fahn), Armando Riesco (Tavo), Marin Ireland (Elena), Shirley Roeca (Ines), Robert Lupone (Dr. Arnold Soltman), Beau Sia (Randy), Sakina Jaffrey (O.R. Nurse)
• And: Julie Benz (Christina Holt)
• Co-Starring: Samuel Mercedes (Robert), Sebastian Martinez (Ernesto), Sue Jean Kim (Chief Nurse), Marsha Stephanie Blake (O.R. Nurse), Quincy Dunn-Baker (Jogger), Paul Lazar (Dr. Hagos)
• Written By: Susannah Grant
• Directed By: Jonathan Demme

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Gbenga Akinnagbe (Dr. Leo "Bax" Baxter), Raul Esparza (Phillip Romero), Brian Kerwin (Jim Marks), Jenna Stern (Rebecca Marks), Afton C. Williamson (Autumn), Mike Doyle (Victor Lantz), Armando Riesco (Tavo), Teagle Bougere (Harold), Marin Ireland (Elena), Roslyn Ruff (Audrey Lewis), Brynn O'Malley (Liz Martin), Orlagh Cassidy (Joanne)
• Co-Starring: Sue Jean Kim (Nurse Collette), Eric Ruffin (Patrice Lambert), Charles Turner (Mr. Keller), Tom Nelis (Man at Clinica), Isabel Santiago (Mother at Holt)
• Written By: Neal Baer & Daniel Truly
• Directed By: Jonathan Kaplan

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Raul Esparza (Phillip Romero), Gbenga Akinnagbe (Dr. Leo "Bax" Baxter), Chris Jackson (Rafael "Rafe" Douglas), Mike Doyle (Victor Lantz), Brynn O'Malley (Liz Martin), Armando Riesco (Tavo), Aaron Lazar (Steve Powers)
• And: Cara Buono (Carol Gordan)
• Co-Starring: Sue Jean Kim (Nurse Colette), Amina Robinson (Lisa Douglas), Brian Delate (Traffic Cop), Tijuana Ricks (Nurse Charisse), John Windsor-Cunningham (Wealthy Man), Jeannine Moore (Wealthy Woman), Tyler Silva (Nathan Douglas), Aaron Bantum (Paolo)
• Written By: Jonathan Greene
• Directed By: Peter Werner

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Samrat Chakrabarti (Mr. Patel), Mike Doyle (Victor Lantz), Purva Bedi (Mrs. Patel), Donnetta Lavinia Grays (Lucille Maxwell), Armando Riesco (Tavo), Ritesh Rajan (Samir Patel)
• And: Julie Benz (Christina Holt)
• Co-Starring: Roslyn Ruff (Nurse Sulla), Amir Ali Said (Davion Maxwell), Eden Wiggins (Tasha Maxwell), Izzy Ruiz (Officer Rodriquez), Alejandra Reyes (Barista)
• Written By: Alison Tatlock
• Directed By: Jonathan Kaplan

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Peter Hermann (Harrison Curtis), Samantha Futerman (Monica Lee), José Ramón Rosario (Agent Frank Zyckner), Darlena Tejeiro (Corina / Renata Ruiz), Andrew Pang (Gordon Lee)
• And: Eriq La Salle (Evan "E-Mo" Morris)
• Co-Starring: Sue Jean Kim (Nurse Colette), Tijuana Ricks (Nurse Charisse), Ben Hollandsworth (PJ), Silvestre Rasuk (Alex Hernandez), Juan Mirt (David Ruiz), Jillian Mueller (Friend of Monica), Brian Costello (Locker Guy), Katie Ross (Nurse Maria)
• Written By: Daniel Truly
• Directed By: David Platt

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Jose Zuniga (Richard Flores), Allan Louis (Donnie), Paula Devicq (Dr. Elizabeth Salinger), James Martinez (George), Mike Doyle (Victor Lantz), Victoria Cartagena (Maria), Alexandra Socha (Chloe Salinger)
• Co-Starring: Roslyn Ruff (Nurse Sulla), Tijuana Ricks (Nurse Charisse)
• Written By: Lisa Melamed
• Directed By: David Platt

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Mamie Gummer (Gemma), K. Todd Freeman (Officer Dale Woodrow), Melissa Errico (Julie Tucker), Marin Ireland (Nurse Elena), Austin Williams (Steven Tucker)
• With: John Benjamin Hickey (Ben Tucker)
• And: Eriq La Salle (Evan "E-Mo" Morris)
• Co-Starring: Joel De La Fuente (Anesthesiologist), Michael Cullen (Chief John Hawthorne), Tijuana Ricks (Nurse Charisse)
• Written By: Adam S. Simon
• Directed By: Peter Werner

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Vondie Curtis Hall (Dennis Jones), Aaron Dean Eisenberg (Lenny), Liam Aiken (Milo), Afton Williamson (Autumn), Mike Doyle (Victor Lantz), Diane Kagan (Mrs. Barnes)
• With: Tom Wopat (Len Hall)
• And: Julie Benz (Christina Holt)
• Co-Starring: Marsha Stephanie Blake (Kelly Jones), Adrian Martinez (Hector), Tijuana Ricks (Nurse Charisse), Sue Jean Kim (Nurse Colette), Tom Greer (Officer Royce), Chris Barnes (Bus Driver), Ben Sinclair (Drunk #1), Fiona Choi (Tessa), Terrence Colby Clemons (ESU Sergeant Black), Aaron Ramey (Drunk #2), Rodney Roldan (Paramedic)
• Written By: Jonathan Greene
• Directed By: Donna Deitch

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Faith Prince (Elinor Lewis), Afton Williamson (Autumn), Mike Doyle (Victor Lantz), Armando Riesco (Tavo), Tom Lipinski (Hank), Megan Ketch (Julia), Kelli Barrett (Rachel Lewis)
• Co-Starring: Roslyn Ruff (Nurse Sulla), Anne Horak (Gina Drake), Jacob Villalobos (Alberto), Michele Vazquez (Alberto's Mom), Ted Schneider (Goateed Man), Nicole Lewis (Paramedic #1), Dario Barosso (Kid)
• Written By: Becky Mode
• Directed By: Constantine Makris

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Becky Ann Baker (Mary Polanco), Afton Williamson (Autumn), Lance Chantiles-Wertz (Dante Crim), Laura Jordan (Theresa Crim), Chris Sullivan (Biker)
• Co-Starring: Adrian Martinez (Hector), Chinasa Ogbuagu (Paramedic), Antwayn Hopper (Marty Polanco), Quincy Chad (Nervous Husband), Badia Farha (Pregnant Woman), Maria Farrow (Surgeon #1), Christopher J. Winfree, M.D. (Surgeon #2)
• Written By: Dawn DeNoon
• Directed By: John David Coles

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Special Guest Star: Leland Orser (Charlie Reinhart)
• And: Eriq La Salle (Evan "E-Mo" Morris)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Dana Wheeler-Nicholson (Jayne Reinhart), Afton Williamson (Autumn), Britt Lower (Nina)
• And: Julie Benz (Christina Holt)
• Co-Starring: Adrian Martinez (Hector), Kailani Coba (Maribel Lopez), Tijuana Ricks (Nurse Charisse), Sol Miranda (Cecelia Gonzales)
• Written By: Lisa Melamed & Alison Tatlock
• Directed By: Adam Bernstein

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Special Guest Star: Eriq La Salle (Evan "E-Mo" Morris)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Peter Hermann (Harrison Curtis), Mike Doyle (Victor Lantz), Austin Lysy (Darren Halloren), Heléne Yorke (Ella Halloren), Chivonne Michelle (Shari Jackson), Adrian Martinez (Hector), Donna Vivino (Rhonda), Stephen Badalamenti (Truck Driver)
• And: John Doman (Coach)
• Co-Starring: Roslyn Ruff (Nurse Sulla), Katie Ross (Nurse Maria), Antoinette Robertson (Girl Basketball Player)
• Written By: Zachary Lutsky
• Directed By: Peter Leto

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Rhys Coiro (Dr. Zeke Barnes), Diane Neal (Attorney Kim Fletcher), Peter Hermann (Harrison Curtis), Desmin Borges (Eduardo Sanchez), David Wilson Barnes (Paul Mathis), Fatima Ptacek (Pilar Sanchez), Lee Sheperd (Judge Parker Whitford), JC Montgomery (ADA Harris Stetham), Chris Bert (Jake Preston)
• With: Robin Weigert (Tracy Mathis)
• And: Julie Benz (Christina Holt)
• Co-Starring: Edvin Ortega (EMT #1), Avery Glymph (NYPD Patrol Cop), Jeffrey C. Hawkins (Jake's Father), Mackenzie Grey (Rebecca Mathis), Regina Schneider (Jake's Mother), Tijuana Ricks (Nurse Charisse), Katie Ross (Nurse Maria)
• Written By: Daniel Truly & Jonathan Greene
• Directed By: Edward Ornelas

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton), Rhys Coiro (Zeke)
• And: Rachelle Lefevre (Kate)
• Special Guest Star: Christina Milian (Shawnee)
• Guest Starring: Michael Beach (Nicky Davis), Afton Williamson (Autumn), Peter Hermann (Harrison Curtis), Ylfa Edelstein (Ileana Albescu), Peter Maloney (Mr. Janowitz), Ursula Parker (Simona Albescu), Adrian Martinez (Hector), Paloma Guzman (Kylie Trevane)
• And: Julie Benz (Christina Holt)
• Co-Starring: Sue Jean Kim (Nurse Collette), Katie Ross (Nurse Maria), Deborah Baum (Bartender), Ben Nordstrom (Businessman), Paul Sanderson (Complaining Man), Cameron Ocasio (Boy With Ball)
• Written By: Dawn DeNoon
• Directed By: Eriq La Salle

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton), Rhys Coiro (Zeke)
• And: Rachelle Lefevre (Kate)
• Special Guest Star: Eriq La Salle (Evan "E-Mo" Morris)
• Guest Starring: Lee Tergesen (Paul Curtis), Mike Doyle (Victor Lantz), Saidah Arrika Ekulona (Dr. Henderson)
• With: Peter Scanavino (Scotty Cartolano)
• And: Maggie Siff (Lily Meyerson)
• Co-Starring: Tijuana Ricks (Nurse Charisse), Sue Jean Kim (Nurse Collette), Katie Ross (Nurse Maria), Tova Katz (Mia), Devon Craig Johnson (Tony), Aaron Livingston (Kyle)
• Written By: Alison Tatlock & Lisa Melamed
• Directed By: Constantine Makris

• Starring: Patrick Wilson (Michael Holt), Jennifer Ehle (Anna Paul), Margo Martindale (Rita), Pablo Schreiber (Anton), Rhys Coiro (Zeke)
• And: Rachelle Lefevre (Kate)
• Guest Starring: Aya Cash (Trish Sulloway), Santino Fontana (Gene Tipton), Charlie Semine (Joel Mitchell), Afton Williamson (Autumn), Mike Doyle (Victor Lantz), Peter Hermann (Harrison Curtis)
• With: Tammy Blanchard (Louise Mitchell)
• And: Frances Fisher (Blanche Tipton)
• Co-Starring: Stephen Reich (Passerby), Matthew Schechter (Boy), Arthur French (Elderly Man), Phil McGlaston (Cab Driver), William S. Brown (Truck Driver), Maria Farrow (Nurse #1), Katie Ross (Nurse Maria), Kate Levy (Emcee)
• Teleplay By: Neal Baer & Daniel Truly
• Story By: Adam S. Simon
• Directed By: David Platt