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• Special Guest Star: Robin Tunney (Rebecca Adler)
• Guest Starring: Andrew Airlie (Orange Colored Patient)
• Co-Starring: Reika Sharma (Melanie Landon), Maya Massar (Asthma Mom), Dylan Basu (Asthma Boy), Ava Rebecca Hughes (Sydney), Kyarra Willis (Kid #2), Eitan Kyle Gross (Molnar), Candus Churchill (Substitute Teacher), Michale Ascher (Egg Salad Lady), Alana Husband (Tech), Janet Glassford (Reception Nurse)
• Written By: David Shore
• Directed By: Bryan Singer

• Guest Starring: Scott Mechlowicz (Dan), Robin Thomas (Dan's Father), Wendy Gazelle (Dan's Mother), Alex Skuby (John Funsten)
• Co-Starring: Kylee Cochran (Young Woman), Paul Ganus (Trainer), Scott Hochstadt (Jake)
• Written By: Lawrence Kaplow
• Directed By: Peter O'Fallon

• Guest Starring: Kevin Zegers (Brandon Merrell), Alexis Thorpe (Mindy)
• And: Faith Prince (Becky Merrell)
• Co-Starring: Lauren Cohn (Jodi Matthews), Marco Pelaez (Hospital Pharmacist), Jason Stuart (Adam Brown), Ben Campbell (Jerry Morris), John Kelly (Robert Merrell), Joshua Wolf Coleman (Suburban Pharmacist), Beth Hall (Shelly Lever)
• Written By: David Shore
• Directed By: Bryan Singer

• Guest Starring: Ever Carradine (Karen Hartig), Hedy Burress (Jill), Cress Williams (Hospital Attorney), Melissa Marsala (Lupino), Alexandra Chun (Kim Chen), Kenneth Choi (Dr. Lim), Ben Parrillo (Dr. Kubisak)
• And: Sam Trammell (Ethan Hartig)
• Co-Starring: Dwight Armstrong (Charlie), Shawn Carter Peterson (Male Med Student), Nate Torrence (Young Man), Jocelyn Jackson (Young Woman), Marc Menard (Soap Doctor), Madison Bauer (Soap Patient), Donna Stearns (Volunteer)
• Written By: Peter Blake
• Directed By: Newton Thomas Sigel

• Guest Starring: Elizabeth Mitchell (Sister Mary Augustine), Lucinda Jenney (Sister Mary Eucharist), Dakin Matthews (Marvin - Santa Claus), Lori Rom (Sister Mary Pius)
• And: Ann Dowd (Mother Superior)
• Co-Starring: Taji Coleman (Tech), James Symington (Priest)
• Written By: Sara B. Cooper
• Directed By: Greg Yaitanes

• Guest Starring: Stacy Edwards (Lucy Palmeiro), Aaron Himelstein (Luke Palmeiro), Al Espinosa (Dr. Wells), John Prosky (Dr. Bergin)
• Co-Starring: Sonya Eddy (Sally), Pat Musick (Trina Wyatt), David Vegh (Clark), Lilas Lane (Terri), Veronica Leigh (Wendy), C. Xavier Drayton (Male Truant Officer)
• Written By: John Mankiewicz
• Directed By: Peter Medak

• Guest Starring: Dominic Purcell (Ed Snow), Myndy Crist (Elise Snow), Brennan Elliott (Adam), Clementine Ford (Samantha Campbell), Henri Lubatti (Master Chef)
• Co-Starring: Endre Hules (Sous Chef), James Conkle (Young Boy)
• Written By: Thomas L. Moran
• Directed By: Bryan Spicer

• Guest Starring: Roxanne Hart (Margo Davis), John Patrick Amedori (Matt Davis), Kurt Fuller (Mark Adams), Andy Milder (Bus Driver), McNally Sagal (Mrs. Miller)
• And: Shirley Knight (Georgia Adams)
• Co-Starring: Jim Lau (Chou-Young Ling), Linda Wang (Jen Ling), Molly Mankiewicz (Amy), Kenya D. Williamson (Nurse), Christopher Malpede (Math Whiz), Ulysses Lee (Chi Ling)
• Written By: Matt Witten
• Directed By: Guy Ferland

• Guest Starring: Harry Lennix (John Henry Giles), Chloe Webb (Cora), Mike Starr (Willie), Victor Raider-Wexler (Judge Winter), Rif Hutton (Morris), Michael Oberlander (Ross)
• With: David Conrad (Marty Hamilton)
• And: Brandy (Herself)
• Co-Starring: Clint Baker (Tommy), Courtney Henggeler (Server), Dennis Howard (Chaplain), Richard Sinclair (Doctor)
• Written By: David Foster
• Directed By: Frederick K. Keller

• Guest Starring: Leslie Hope (Victoria Madsen), Larry Clarke (Officer Gilmar), Smith Cho (Julia), Ogy Durham (Chris Dewey)
• Co-Starring: Leslie Karpman (Jodi), Charles C. Stevenson, Jr. (Walter), Suzanne Ford (Mrs. Whitney), Tomiko Martinez (Tall Girl), Patty Onagan (Girlfriend), Bonnie Perlman (Mom), Farrah Skyler Greye (Nurse), Troy Robinson (Cop #1), Paul Sklar (Cop #2), Kevin Moon (EMT), Brandon Brocato (Phil)
• Written By: Joel Thompson
• Directed By: Daniel Attias

• Guest Starring: Mark Harelik (Mr. Foster), Nicholas D'Agosto (Keith Foster), Amanda Seyfried (Pam), Maurice Godin (Dr. Hourani)
• Co-Starring: Marco Pelaez (Pharmacist), Ameríca Olivo (Ingrid), Akiko Ann Morison (Anesthesiologist)
• Written By: Lawrence Kaplow & Thomas L. Moran
• Directed By: Nelson McCormick

• Guest Starring: Scott Foley (Hank Wiggen), Meredith Monroe (Lola), Art LaFleur (Warner Fitch), Salli Richardson-Whitfield (Sharon), Bryan Singer (Himself)
• Co-Starring: Timothy McNeil (Patient #2), Deirdre M. Smith (Carol Moffatt), Sean Everett (Patient #4), Richard Swaidan (College Student)
• Written By: John Mankiewicz & David Shore
• Directed By: Keith Gordon

• Guest Starring: Nestor Carbonell (Jeffrey Reilich), Tracy Middendorf (Sarah Reilich), David Henrie (Tommy)
• With: Daryl Sabara (Gabriel Reilich)
• And: Patrick Bauchau (Dr. Rowan Chase)
• Co-Starring: Dennis Bendersky (Davey), R.J. Root (Sam), Jack Walsh (Ozzy), Abbey McBride (Blonde), Alejandro Patino (Cabbie)
• Written By: Matt Witten & Peter Blake
• Directed By: Daniel Sackheim

• Guest Starring: Sarah Clarke (Carly Forlano), Sunny Mabrey (Jenny), Vivian Bang (Robin), Andrew Borba (Mr. Van Der Meer), Ron Perkins (Dr. Simpson)
• And: Chi McBride (Edward Vogler)
• Co-Starring: Dar Dixon (Don), Joshua Miller (Ricky), David Joyner (Cardiac Surgeon #2), David Castellani (Board Member #2), Sheila Cavalette (Anesthesiologist)
• Written By: Lawrence Kaplow
• Directed By: Randy Zisk

• Guest Starring: Danny Nucci (Bill Arnello), Joseph Lyle Taylor (Joey Arnello), David Burke (Everhardt), AJ Trauth (Henry)
• And: Chi McBride (Edward Vogler)
• Co-Starring: Greg Collins (Marshal Brady), Ingrid Sanai Buron (Kimberly)
• Written By: David Foster & John Mankiewicz
• Directed By: Tim Hunter

• Guest Starring: Cynthia Ettinger (Mrs. Simms), Jennifer Stone (Jessica Simms), Susan Slome (Mrs. Lucille Hernandez), Ramon Franco (Mr. Hernandez), Karen Goberman (Mrs. Ayers)
• And: Chi McBride (Edward Vogler)
• Co-Starring: Teddy Lane, Jr. (Mr. Conroy), Alyson Morgan (Clementine), Austin Leisle (Seth), Rose Colasanti (Cashier), Alec George (Classmate #1), DJ Evans (Classmate #2), Bryan Fabian (Classmate #3)
• Written By: Thomas L. Moran
• Directed By: Fred Gerber

• Guest Starring: Joe Morton (Senator Gary H. Wright), Missy Crider (Susan)
• And: Chi McBride (Edward Vogler)
• Co-Starring: Dominic Oliver (Reynolds), Elizabeth Karr (Hostess), Bobbin Bergstrom (ICU Nurse), Sahar Bibiyan (Clinic Nurse)
• Written By: Matt Witten
• Directed By: Peter O'Fallon

• Guest Starring: Marin Hinkle (Naomi Randolph), Michael Goorjian (Sean Randolph), Michael Simpson (Joel Kaplan), Natalie Shaw (Rachel Kaplan), Ron Perkins (Dr. Simpson), Kenneth Choi (Dr. Lim)
• And: Chi McBride (Edward Vogler)
• Co-Starring: John Berg (Dr. Prather), S.E. Perry (Officer Davis), Guy Camilleri (Hayden Brown), Kevin Brief (Officer Angle), Diane Sellers (Gail Friedman), Veronica Brown (Female Boardmember), Reggie Jordan (Anesthesiologist)
• Teleplay By: Peter Blake & David Shore
• Story By: Peter Blake
• Directed By: Bill Johnson

• Guest Starring: Eddie McClintock (Coach Stahl), Ben Jelen (Dr. Roger Spain), Shari Headley (Dr. Arlene Marks), Erin Foster (Dr. Petra Gilmar), Dylan Kussman (Mr. Carroll), Stephanie Venditto (Nurse Brenda Previn)
• And: Skye McCole Bartusiak (Mary Carroll)
• Co-Starring: Kelly Kirklyn (Mrs. Carroll), Tim Haldeman (Mature Man), Geraldine Singer (Woman), Cindy Lu (Nurse), Mark Bloom (Doc #1), Eric Cazenave (Doc #2), Lindsay Pulsipher (Teammate #1), Rhea Lando (Teammate #2), Diego Clare (Dawson)
• Written By: Thomas L. Moran & Lawrence Kaplow
• Directed By: Deran Sarafian

• Guest Starring: John Cho (Harvey Park), Christina Cox (Annette Raines), Matt Malloy (Aubrey Shifren), June Squibb (Ramona), Keone Young (Clyde Park), Elizabeth Sung (Marilyn Park), Kristoffer Winters (New Guy), Stephanie Venditto (Nurse Brenda Previn)
• And: Peter Graves (Myron)
• Co-Starring: Marco Pelaez (Pharmacist), Tom Knickerbocker (Dr. May)
• Written By: Sara B. Cooper
• Directed By: Bryan Spicer

• Special Guest Star: Sela Ward (Stacy Warner)
• Guest Starring: Nicole Bilderback (Caring Student), Andrew Keegan (Rebellious Student), Josh Zuckerman (Keen Student), Brent Briscoe (Farmer), Stephanie Venditto (Nurse Brenda Previn), James Saxenmeyer (Late 30s Man)
• And: Carmen Electra (Herself)
• Co-Starring: Andi Eystad (Volleyball Player), Ingrid Sanai Buron (Nurse #3), Bobbin Bergstrom (Nurse #2), Susan Gallagher (Volleyball Player's Mom)
• Written By: David Shore
• Directed By: Paris Barclay

• Special Guest Star: Sela Ward (Stacy Warner)
• Guest Starring: Currie Graham (Mark Warner)
• Co-Starring: Mark Hames (Ambulance Driver), Revital Krawetz (Woman)
• Written By: Lawrence Kaplow & John Mankiewicz
• Directed By: Frederick King Keller