- Ep: 1
- Natural Selection
- Starring: Tatiana Maslany (Sarah / Beth / Katya Obinger), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Inga Cadranel (Angela Deangelis), Ron Lea (Detective Hardcastle), Skyler Wexler (Kira), Elizabeth Saunders (Dr. Anita Bower)
- Cast: Dom Fiore (Police Captain), Justin Skye Conley (Exec), Diana Salvatore (Bobby), Nicholas Rose (Colin), Ivan Sherry (Internal Affairs Suit), Marqus Bobesich (Rockabilly Bob), Jamila Fleming (Sherry), Jean-Michel Le Gal (Stephen Riggs), Janette Luu (Reporter), Denika Ellis-Dawson (Little Girl), Joanne Reece (Beth's Lawyer), Audra Yolanda Gray (Woman), Eileen Li (Receptionist)
- Written By: Graeme Manson
- Directed By: John Fawcett
- Ep: 2
- Instinct
- Starring: Tatiana Maslany (Sarah / Beth / Katya Obinger), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Inga Cadranel (Angela Deangelis), Ron Lea (Detective Hardcastle), Skyler Wexler (Kira), Elizabeth Saunders (Dr. Anita Bower)
- Cast: Dom Fiore (Police Captain), Reid Janisse (Desk Clerk), Dale Samms (Hotel Security), Ivan Sherry (Internal Affairs Suit), Joanne Reece (Beth's Lawyer), Millie Davis (Gemma), Drew Davis (Oscar), Marqus Bobesich (Rockabilly Bob), Jamila Fleming (Sherry)
- Written By: Graeme Manson
- Directed By: John Fawcett
- Ep: 3
- Variation Under Nature
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Inga Cadranel (Angela Deangelis), Ron Lea (Detective Hardcastle), Skyler Wexler (Kira), Kristian Bruun (Donnie Hendrix), Natalie Lisinska (Aynsley)
- Cast: Millie Davis (Gemma), Drew Davis (Oscar), Ray Ablack (Raj), Jean Yoon (Janis Beckwith), Tyler Murree (Forensic Clerk), Diana Galligan (Female Cop), Chris Seivright (Bartender), Diane Fabian (Ukranian Landlady)
- Written By: Graeme Manson
- Directed By: David Frazee
- Ep: 4
- Effects of External Conditions
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Inga Cadranel (Angela Deangelis), Ron Lea (Detective Hardcastle), Skyler Wexler (Kira), Kristian Bruun (Donnie Hendrix)
- Cast: Ray Ablack (Raj Singh), Jean Yoon (Janis Beckwith), Jack Fulton (Trevor), Jane Spence (Trevor's Mom), Jamillah Ross (ND Officer), Michael Brown (SWAT Officer), Lila Yee (Old Lady)
- Written By: Karen Walton
- Directed By: Grant Harvey
- Ep: 5
- Conditions of Existence
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Evelyne Brochu (Delphine), Daniel Kash (Tomas), Skyler Wexler (Kira), Kristian Bruun (Donnie Hendrix), David Richmond-Peck (Olivier)
- Cast: Millie Davis (Gemma), Drew Davis (Oscar), Ray Ablack (Raj), Nicholas Rose (Colin), Miriam McDonald (Madison), Marty Adams (Spytech Clerk), Josh Vokey (Scott), Tony Cianchino (Pouchy), David Vena (Joao), Daniel Park (Doctor #1), Vitalie Ursu (Doctor #2)
- Written By: Alex Levine
- Directed By: TJ Scott
- Ep: 6
- Variations Under Domestication
- Starring: Tatiana Maslany (Sarah / Alison / Cosima), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Matt Frewer (Dr. Leekie), Evelyne Brochu (Delphine), Kristian Bruun (Donnie Hendrix), Natalie Lisinska (Aynsley Norris), David Richmond-Peck (Olivier), Eric Johnson (Chad Norris)
- Cast: Millie Davis (Gemma), Drew Davis (Oscar), Kristi Angus (Charity Simms), Priya Rao (Meera Kumar), Earl Bubb McLean (Teddy)
- Written By: Will Pascoe
- Directed By: John Fawcett
- Ep: 7
- Parts Developed in an Unusual Manner
- Starring: Tatiana Maslany (Sarah / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Matt Frewer (Dr. Leekie), Evelyne Brochu (Delphine), Skyler Wexler (Kira), David Richmond-Peck (Olivier), Sarain Boylan (Astrid), Daniel Kash (Tomas)
- Cast: Inga Cadranel (Angela Deangelis), Ron Lea (Lieutenant Gavin Hardcastle), Jean Yoon (Janis Beckwith), Nicholas Rose (Colin), Edsson Morales (Coat Check Boy), Jessica-Lynn Doucett (Practitioner), Jeremy Hernandez (Clubber)
- Written By: Tony Elliott
- Directed By: Brett Sullivan
- Ep: 8
- Entangled Bank
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Matt Frewer (Dr. Leekie), Evelyne Brochu (Delphine), David Richmond-Peck (Olivier), Skyler Wexler (Kira), Natalie Lisinska (Aynsley Norris), Eric Johnson (Chad Norris), Ron Lea (Lieutenant Hardcastle), Inga Cadranel (Angela Deangelis)
- Cast: Nicholas Rose (Colin), Priya Rao (Meera Kumar), Sanjay Talwar (Dr. Aguda), Jeff Yung (Orderly)
- Written By: Karen Walton
- Directed By: Ken Girotti
- Ep: 9
- Unconscious Selection
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Matt Frewer (Dr. Leekie), Skyler Wexler (Kira), Kristian Bruun (Donnie Hendrix), Melanie Nicholls-King (Amelia), Inga Cadranel (Angela Deangelis), Ron Lea (Lieutenant Hardcastle), Evelyne Brochu (Delphine), Daniel Kash (Tomas), Natalie Lisinska (Aynsley)
- Cast: Nicholas Rose (Colin), Josh Vokey (Scott), Kristi Angus (Charity Simms), Priya Rao (Meera Kumar), Ryan Blakely (Reverend Mike), Billy Parrott (EMT), Jarret Wright (Doctor), Okiki Kendall (Nurse 1), Jennifer Krukowski (Nurse 2), Azdin Zaman (Meera's Husband), Neil Girvan (Charity's Husband), Rob Trick (Track Worker), Louise Nicol (Donnie's Mother)
- Written By: Alex Levine
- Directed By: TJ Scott
- Ep: 10
- Endless Forms Most Beautiful
- Starring: Tatiana Maslany (Sarah / Alison / Cosima / Helena / Rachel), Dylan Bruce (Paul), Jordan Gavaris (Felix), Kevin Hanchard (Art), Michael Mando (Vic)
- And: Maria Doyle Kennedy (Mrs. S)
- Guest Starring: Matt Frewer (Dr. Leekie), Skyler Wexler (Kira), Kristian Bruun (Donnie Hendrix), Natalie Lisinska (Aynsley Norris), Inga Cadranel (Angela Deangelis), Ron Lea (Lieutenant Hardcastle), Evelyne Brochu (Delphine), Melanie Nicholls-King (Amelia)
- Cast: Josh Vokey (Scott), Matthew Bennett (David Rosen)
- Written By: Graeme Manson
- Directed By: John Fawcett
| Tatiana Maslany .... Sarah Manning / Beth Childs / |
| ................. Katja Obinger / Alison Hendrix / |
| .......... Cosima Niehaus / Helena / Rachel Duncan |
| Dylan Bruce ................................. Paul |
| Jordan Gavaris ..................... Felix Dawkins |
| Kevin Hanchard ................ Detective Art Bell |
| Michael Mando ................................ Vic |
| Maria Doyle Kennedy ...... Siobhan "Mrs. S" Sadler |
