| Jovan Adepo ... Dr. Saul Durand |
| Rosalind Chao ... Dr. Ye Wenjie |
| Liam Cunningham ... Thomas Wade |
| Eiza González ... Dr. Augustina "Auggie" Salazar |
| Jess Hong ... Dr. Jin Cheng |
| Marlo Kelly ... Tatiana Haas |
| Alex Sharp ... Dr. Will Downing |
| Sea Shimooka ... Sophon |
| Zine Tseng ... Young Ye Wenjie |
| Saamer Usmani ... Prithviraj "Raj" Varma |
| Benedict Wong ... Clarence "Da" Shi |
