| Nicole Sullivan ... Joan of Arc |
| Mitra Jouhari ... Cleopatra |
| Will Forte ... Abe Lincoln / Narrator |
| Christopher Miller ... JFK / Mr. Butlertron |
| Vicci Martinez ... Frida Kahlo |
| Ayo Edebiri ... Harriet Tubman |
| Kelvin Yu ... Confucius |
| Neil Casey ... Topher Bus |
| Donald Faison ... George Washington Carver |
| Phil Lord ... Principal Dr. Cinnamon J. Scudworth |
| Christa Lawrence ... Superintendent Candide Sampson |
