| Emily Watson ... Valya Harkonnen |
| Olivia Williams ... Tula Harkonnen |
| Jodhi May ... Empress Natalya |
| Sarah-Sofie Boussnina ... Princess Ynez |
| Shalom Brune-Franklin ... Mikaela |
| Faoileann Cunningham ... Sister Jen |
| Aoife Hinds ... Sister Emeline |
| Chloe Lea ... Lila |
| Travis Fimmel ... Desmond Hart |
| Mark Strong ... Emperor Javicco Corrino |
| Jade Anouka ... Sister Theodosia |
| Chris Mason ... Keiran Atreides |
