Guest Starring: Marshall Bell (Warden), Christie Lynn Smith (Cindy Kramer), Bryce Johnson (James), Mustafa S. Shakir (D'Vontray)
And: LL Cool J (Clarence)
Co-Starring: Jody L. Millard (Guard), Michael J. Gonzalez (Carlos), Tony Ross (Emmitt), Anesha Ndiaye (Darriene), Warren Davis (Kent), Michael Dietz (John Clift), Adrienne Janic (Dr. Vivian), Joseph Williamson (Dr. Bruce)
Written By: Russel Friend & Garrett Lerner
Directed By: Dan Attias
Ep: 24
Autopsy
Guest Starring: Sasha Pieterse (Andie), Jewel Christian (Pam), Randall Park (Brad), Stephanie Venditto (Nurse Brenda Previn)
Co-Starring: Eamon Hunt (Neurosurgeon), William Jones (Dr. Murphy), Hira Ambrosino (Anesthesiologist), Gwen Holloway (Neurosurgeon #2), Jonathan Fraser (Salesperson)
Written By: Lawrence Kaplow
Directed By: Deran Sarafian
Ep: 25
Humpty Dumpty
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Ignacio Serricchio (Alfredo), Charlie Robinson (Robert), Christine Avila (Luisa), JR Villarreal (Manny)
Written By: Matt Witten
Directed By: Dan Attias
Ep: 26
TB or Not TB
Guest Starring: Ron Livingston (Dr. Sebastian Charles), Andrea Bendewald (Cecilia Carter)
Co-Starring: Ken Weiler (Jerry), Mary Wickliffe (Mandy), Hansford Prince (Bogale), Joram Moreka (Father), Harry F. Brockington IV (Dahoma)
Co-Starring: Matt McKenzie (Dr. Fedler), Brian D. Johnson (Taddy's Boss), Jon Hershfield (Timekeeper), Mackenzie English (Katrina), Brian Chase (EMT), Bobbin Bergstrom (O.R. Nurse)
Written By: Thomas L. Moran
Directed By: Greg Yaitanes
Ep: 28
Spin
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Currie Graham (Mark Warner), Alanna Ubach (Dr. Louise Harper), Tom Lenk (Allen)
With: Taraji P. Henson (Moira)
And: Kristoffer Polaha (Jeff Forrester)
Co-Starring: Patrick Roman Miller (Maintenance Man), Drew Gardner (Blind Guy), Scott Kradolfer (Matthew's Father), Julie Quinn (Matthew's Mother), Nathan Kress (Scott), Austin Whitlock (Matthew)
Written By: Sara Hess
Directed By: Fred Gerber
Ep: 29
Hunting
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Currie Graham (Mark Warner), Matthew John Armstrong (Kalvin), Wings Hauser (Michael)
Co-Starring: Hamilton Mitchell (Infection Control Officer)
Written By: Liz Friedman
Directed By: Gloria Muzio
Ep: 30
The Mistake
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Ryan Hurst (Sam), Allison Smith (Kayla), John Rubinstein (Dr. Ayersman), John Lafayette (Dr. Schisgal), Greg Winter (Chuck), Stephanie Venditto (Nurse Brenda Previn)
Co-Starring: Nell Rutledge (Hailey), Xhercis (Imelda), David DeSantos (ER Doctor), Patrick LoSasso (Do-Gooder), Larry Weissman (Fat Man), Rod Britt (Teller), Peter Abbay (Cab Driver)
Written By: Michael R. Petty
Directed By: Deran Sarafian
Ep: 32
Failure to Communicate
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Mimi Kennedy (Greta), Erica Gimpel (Elizabeth Stone), Bruce French (Peter Foster)
And: Michael O'Keefe (Fletcher Stone)
Co-Starring: Pat Caldwell (Mary Jean), Derek Anthony (Guard), Amy Margolis (Mother), Michael Len (9 Year Old Boy)
Written By: Doris Egan
Directed By: Jace Alexander
Ep: 33
Need to Know
Special Guest Star: Sela Ward (Stacy Warner)
Guest Starring: Currie Graham (Mark Warner), Edward Kerr (Ted Dalton), Elle Fanning (Stella Dalton)
And: Julie Warner (Margo Dalton)
Co-Starring: Holly Daniels (Debbie)
Written By: Pamela Davis
Directed By: David Semel
Ep: 34
Distractions
Guest Starring: Lisa Darr (Emily), Christopher Cousins (Doug), Dan Butler (Dr. Weber), James Immekus (Adam), Stephanie Venditto (Nurse Brenda Previn)
Co-Starring: Michael Merton (Anesthesiologist), Judy Louise Johnson (Surgeon), Dorothea Harahan (EMT), Kristen Pate (Paula)
Written By: Lawrence Kaplow
Directed By: Dan Attias
Ep: 35
Skin Deep
Guest Starring: Tom Verica (Martin), Cameron Richardson (Alex), James Dumont (George), Stephanie Venditto (Nurse Brenda Previn), Karis Campbell (Pregnant Woman), Donzaleigh Abernathy (Brady)
Co-Starring: John Burke (Austin)
Teleplay By: Russel Friend & Garrett Lerner & David Shore
Story By: Russel Friend & Garrett Lerner
Directed By: Jim Hayman
Ep: 36
Sex Kills
Guest Starring: Greg Grunberg (Ronald Neuberger), Keri Lynn Pratt (Amy Errington), Adam Busch (Tony), Ron Perkins (Dr. Simpson), Yvette Nicole Brown (Ellen Stambler)
And: Howard Hesseman (Henry Errington)
Co-Starring: Craig Patton (2nd Table East), Susan Grace (1st Table North), Noel Conlon (1st Table East), Marcie Lynn Ross (2nd Table West), Jean St. James (Cecile), Stephen DeCordova (2nd Chief Surgeon), Bobbin Bergstrom (ER Doctor)
Guest Starring: Laura Allen (Sarah Alston), Mackenzie Astin (Alan Alston), Carter Page (Ian Alston), Al Espinosa (Dr. Wells), Michelle Harrison (Nicole Ballard), Purva Bedi (Teacher)
Co-Starring: Daylon Reese (Child)
Written By: David Foster
Directed By: Fred Gerber
Ep: 40
Sleeping Dogs Lie
Guest Starring: Jayma Mays (Hannah), Dahlia Salem (Max)
Co-Starring: Julia Ling (Anne), Alice Lo (Mrs. Ling), KT Thangavelu (Surgeon), Kendall Clement (Anesthesiologist)
Written By: Sara Hess
Directed By: Greg Yaitanes
Ep: 41
House vs God
Guest Starring: Thomas Dekker (Boyd), William Katt (Walter), Tamara Braun (Grace)
Co-Starring: David Cheaney (Bus Stop), Michael Edwin (Tax Accountant), Marco A. Martinez (Dry Cleaner), Sandra Marshall (Agnes), Will Rogers (Pastor)
Written By: Doris Egan
Directed By: John F. Showalter
Ep: 42
Euphoria, Part 1
Guest Starring: Scott Michael Campbell (Joe Luria), Loreni Delgado (Haines)
Co-Starring: Chioke Dmachi (Baby Shoes), Chil Kong (Morgue Tech), Guy Nardulli (Coughing Cop), Calvin King (Transvestite)
Written By: Matthew V. Lewis
Directed By: Deran Sarafian
Ep: 43
Euphoria, Part 2
Guest Starring: Charles S. Dutton (Rodney Foreman), Scott Michael Campbell (Joe Luria), Leigh-Allyn Baker (Claire)
Co-Starring: Amber DeMarco (Rose)
Written By: Russel Friend & Garrett Lerner & David Shore
Directed By: Deran Sarafian
Ep: 44
Forever
Guest Starring: Kip Pardue (Brent Mason), Hillary Tuck (Kara Mason), Toni Lewis (NICU Nurse)
Co-Starring: Kevin Moon (EMT)
Written By: Liz Friedman
Directed By: Daniel Sackheim
Ep: 45
Who's Your Daddy?
Guest Starring: D.B. Sweeney (Dylan Crandall), Aasha Davis (Leona), Christopher Carley (Patrick Linehan), Ameríca Olivo (Ingrid)
Co-Starring: Tuffet Schmelzle (Young Mother), Owen Pearce (Max), Krista Lewis (Flight Attendant)
Teleplay By: John Mankiewicz & Lawrence Kaplow
Story By: Charles M. Duncan & John Mankiewicz
Directed By: Martha Mitchell
Ep: 46
No Reason
Guest Starring: Elias Koteas (Jack Moriarty), Michelle Clunie (Judy), Chris Tallman (Vince)
Co-Starring: Obie Sims (Cuddy's Patient), Bobbin Bergstrom (Nurse)
