Season One
| Steve Blum ... Wolverine / Vanisher |
| Clancy Brown ... Mister Sinister |
| AJ Buckley ... Toad |
| Susan Dalian ... Storm |
| Liza Del Mundo ... Polaris |
| Richard Doyle ... Senator Robert Kelly |
| Jennifer Hale ... Jean Grey |
| Mark Hildreth ... Quicksilver |
| Tamara Evans ... Mystique |
| Kate Higgins ... Scarlet Witch / Pixie |
| Michael Ironside ... Colonel Moss |
| Danielle Judovits ... Shadowcat |
| Tom Kane ... Magneto / Dr. Cornelius / Professor Thornton |
| Phil LaMarr ... Gambit / Bolivar Trask |
| Peter Lurie ... Sabretooth |
| Yuri Lowenthal ... Iceman |
| Liam O'Brien ... Nightcrawler / Angel / Nitro |
| Nolan North ... Cyclops / Pyro |
| Kevin Michael Richardson ... Bishop |
| Roger Craig Smith ... Forge / Hellion |
| Stephen Stanton ... Blob |
| Tara Strong ... Marrow / Dust |
| James Patrick Stuart ... Avalanche |
| Fred Tatasciore ... Beast / Hulk / Juggernaut |
| Kieren van den Blink ... Rogue |
| Kari Wahlgren ... Emma Frost / Dr. Sybil Zane / Magma |
| Jim Ward ... Professor X / Colossus / Warren Worthington II |
| Gwendoline Yeo ... Domino |