Alphas follows a team of ordinary citizens whose brain anomalies imbue them with extraordinary mental and physical abilities. Taking the law into their own hands, the unlikely team, led by Dr. Lee Rosen, investigates cases that suggest other Alpha activity to uncover what the CIA, FBI and Pentagon have not been able, or willing, to solve. These gifted individuals must balance their quirky personalities and disparate backgrounds with their not always visible powers as they work to solve crimes, stop the ticking time bomb and catch the enemy.