After saving the life of the President, two Secret Service agents find themselves abruptly transferred to Warehouse 13 -- a massive, top-secret storage facility in windswept South Dakota that houses every strange artifact, mysterious relic, fantastical object and supernatural souvenir ever collected by the U.S. government. The Warehouse's caretaker Artie assigns Pete and Myka the challenge of chasing down reports of supernatural and paranormal activity in search of new objects to store at the Warehouse. The two agents are also commissioned to help Artie control the Warehouse itself, which proves to be a task beyond what either of them could have ever imagined.