Season Ten: Red Tide
| Sarah Paulson ... Tuberculosis Karen |
| Evan Peters ... Austin Sommers |
| Lily Rabe ... Doris Gardner |
| Finn Wittrock ... Harry Gardner |
| Frances Conroy ... Belle Noir |
| Billie Lourd ... Lark |
| Leslie Grossman ... Ursula |
| Adina Porter ... Chief Burleson |
| Angelica Ross ... The Chemist |
| Macaulay Culkin ... Mickey |
| Ryan Kiera Armstrong ... Alma Gardner |
Season Ten: Death Valley
| Sarah Paulson ... Mamie Eisenhower |
| Lily Rabe ... Amelia Earhart |
| Leslie Grossman ... Dr. Calico |
| Angelica Ross ... Theta |
| Neal McDonough ... Dwight "Ike" Eisenhower |
| Kaia Gerber ... Kendall Carr |
| Nico Greetham ... Cal Cambon |
| Isaac Cole Powell ... Troy Lord |
| Rachel Hilson ... Jamie Howard |
| Rebecca Dayan ... Maria Wycoff |