• Guest Starring: Vince Grant (Nathan Tubs), Shawn Michael Patrick (Detective Jim Griffith), Elizabeth Hendrickson (Katie), Shelly Cole (Anna), Jayne Atkinson (Erin Strauss)
• Co-Starring: Amanda MacDonald (Helen), Angela Oh (Stephanie), Tori White (Alisa), Anthony Diaz-Perez (Paul Davies), Moira Price (Suzanne Cable), Kim Estes (Coroner), Alexa Alemanni (Amy), Christina Haag (Female Cop), Tyler Poelle (Cop), Moira Squier (Sarah)
• Written By: Chris Mundy
• Directed By: Gloria Muzio
• Note: This season 2 episode was held back due to the shootings at Virginia Tech. New footage was shot to make it fit in with the present story line.

• Guest Starring: Gordon Clapp (Detective Vic Wolynski), Meredith Monroe (Haley Hotchner), Yvonne Jung (Claire), Chandler Canterbury (David Smith), Jayne Atkinson (Erin Strauss), Eddie Cibrian (Joe Smith)
• Co-Starring: Stefan Marks (Bill Thompson), Grace Renn (Lisa Philips), Mary Ostrow (Pam), Regi Davis (Cop), Lori Skope (Ms. Bennett), Lucia Sullivan (Vicki), Cade Owens (Jack Hotchner), Jacquie Barnbrook (Rose)
• Written By: Chris Mundy
• Directed By: Edward Allen Bernero

• Guest Starring: Michael O'Keefe (Dr. Stan Howard), Matt Bushell (Bill Calvert), Stephanie Venditto (Jane Howard), Jayne Atkinson (Erin Strauss)
• Co-Starring: Danielle Sapia (Missy), John Bobek (Patrick), Jennifer Keyes (Jenny), Randy Crowder (Apartment Super), M.J. Karmi (Howard's Mother), Brandon Killham (Young Howard), Casey Kramer (Landlady), Melody Hollis (Jessica Howard)
• Written By: Debra J. Fisher & Erica Messer
• Directed By: Felix Alcala
• Note: In Memory of Mark Kamps

• Guest Starring: William Lee Scott (Gary), Francis Capra (Ervin), Joanna Flores (Carrie), Stephanie Erb (Dina), Christine Healy (Mrs. Manwaring)
• Co-Starring: Tom Kiesche (Lieutenant Nellis), Mark Doerr (Tom), Bob Rumnock (Supervisor), Masam Holden (Tyler), Laura P. Vega (Ortiz Mother), Alex Castillo (Ortiz Father), Michael FitzGibbon (ER Doctor), Christopher Frontiero (Clerk), Mary Carrig (Carol), Kate Emerick (Sara), Michael Ng (Asian Diner), Garrett Ryan (Hayden), Parker Contreras (Danny Ortiz), Evan Donaldson (Neil), Robert Fisher (Cop in Donut Shop)
• Written By: Dan Dworkin & Jay Beattie
• Directed By: Guy Norman Bee

• Guest Starring: Suzanne Cryer (Susan Jacobs), Paula Malcomson (Beth Jacobs), Emmanuel Xuereb (Richard Jacobs), Salvator Xuereb (Paul Jacobs), Nigel Gibbs (James Franklin), Alexander Gould (Jeremy), Meredith Monroe (Haley Hotchner)
• Co-Starring: Molly Baker (Jessica Brooks), Ariel Winter (Katie), Dikla Marshall (Marie Samuels), Don Danielson (Uni #1), Mark Tomesek (Security Officer), Celeste Den (Agent #1), Kelly Heyer (Teenage Girl), Nathan Pearson (Teenager), Cade Owens (Jack Hotchner)
• Written By: Andi Bushell
• Directed By: John Gallagher

• Guest Starring: Michael O'Neill (Detective Yarbough), Andrew Kavovit (Max Pool), Jayne Atkinson (Erin Strauss)
• Co-Starring: Sandra Dee Robinson (Michelle), Tarri Markell (Enid), Elimu Nelson (Detective Bowie), Kelli Kirkland Powers (News Reporter), Robert C. Sloan (Uniformed Officer), Kelly McCracken (Lieutenant Price)
• Written By: Charles Murray
• Directed By: Skipp Sudduth

• Guest Starring: Michael Cudlitz (Francis Goehring), Kaj-Erik Eriksen (Henry Frost)
• Co-Starring: Danielle Kennedy (Cashier), Kristopher Logan (Trailer Park Manager), Jason Hamer (Robert Miller), Adria Tennor (Diane Goehring), Tammy Minoff (Jennifer Hillbridge), Beth Dover (Angela Miller), Sebastian Naskaris (Employee #3)
• Written By: Oanh Ly
• Directed By: Gwyneth Horder-Payton

• Guest Starring: Bailey Chase (James Colby Baylor), Nick Searcy (Detective Jordan), John LaFayette (Dr. Lorenz), Michael Beach (Father Marks), Jamie Kennedy (Floyd Feylinn Ferell)
• Co-Starring: James Otis (Dr. Nash), John Eric Montana (Dr. Fulton), Gwen Holloway (Lee-Ann Kelton), Daniel Quinn (Bob Kelton), Kate Connor (Sheryl Timmons), Seth William Meier (John Timmons), Liz Montgomery (Board Member #1), Steven Shaw (Board Member #2), Colleen Foy (Tracey Lambert), Ben Carroll (Guard), Matt Riedy (State Trooper), David Lowe (Local Cop), Oliver Wells (Young Unsub - Floyd), Peter Darren (Police Officer)
• Written By: Andrew Wilder
• Directed By: Steve Boyum

• Guest Starring: Bailey Chase (James Colby Baylor), Marc Vann (Adam Fuchs), Nicholas Brendon (Kevin Lynch)
• Co-Starring: John Eddins (Detective Walker), Bruce Katzman (Trauma Surgeon), Loren Lester (Surgeon #2), Andrew Elvis Miller (Medic #1), Sabrina Gennarino (Medic #2), Tamara Zook (Neighbor), Reena Dutt (Nurse), Anne McCarthy (ER Nurse), Paul Vroom (Clerk), Mati Moralejo (Mike Fleming), James Kalagher (Waiter), Christina Gabrielle (Young Garcia - 9), Rebecca Egender (Young Garcia - 20), Maddison Davis (Young Garcia - 5)
• Written By: Chris Mundy
• Directed By: Felix Alcala

• Special Guest Star: Frankie Muniz (Jonny McHale)
• Guest Starring: Parry Shen (Bobby Kim), John Walcutt (Detective Brady), Ellen Hollman (Vickie)
• Co-Starring: Sara Van Horn (Helen Trestle), Craig Gellis (Glen Hill), Steve Richard Harris (Jasper), Johanna Parker (Jean), Marc D. Wilson (Benson), Edward Flores (Gus), Matt Micucci (Milo), David Lengel (Brain), Tom Ohmer (Desk Sergeant), J. Richey Nash (Uniformed Cop), Sherri Howard (ND Detective #1), Eric Tiede (ND Detective #2), Sarah Beth Bassak (Mail Carrier)
• Written By: Edward Allen Bernero
• Directed By: Edward Allen Bernero

• Guest Starring: Sally Pressman (Chrissy Wilkinson), W. Morgan Sheppard (John Caulfield), Dendrie Taylor (Karen Foley), Jennifer Hetrick (Mary Wilkinson), Rodney Eastman (Stephen Foley), Jeffrey Corbett (Michael Ballantyne), Lacey Beeman (Molly)
• Co-Starring: Elizabeth Ann Roberts (Tara), Kandis Erickson (Julie), Curt Bonnem (Charlie Wilkinson), Nathan Sutton (Justin), Jesse Bernstein (Danny), Houston Rhines (Guy), Royce Thomas Johnson (Boy), Erika Whalen (Girl), J. Claude Deering (Man), Rebekah Brandes (Young Karen Foley), Matt Hoffman (Robert Wilkinson)
• Written By: Debra J. Fisher & Erica Messer
• Directed By: John Gallagher

• Special Guest Star: Fredric Lane (Jack Vaughan)
• Guest Starring: Michael Harney (Pat Mannan), Brian McNamara (Bruce Owen), Cheryl White (Lori Owen), Riley Smith (Ryan Phillips), Gina Mantegna (Lindsey), Rick Otto (Detective Payton), Hayley McFarland (Katie Owen), Alex Hyde-White (Grant Silverman)
• Co-Starring: Curtiss Frisle (Taylor Coleman)
• Written By: Simon Mirren
• Directed By: Anthony Hemingway

• Guest Starring: Andrea Roth (FBI Agent Jill Morris), Wendy Braun (Katrina Townsley), Christopher Allen Nelson (Unsub)
• Co-Starring: Michael Cotter (Stu), Madden Page (Auctioneer), Jeremy Cohenour (Dwayne), Chris Snyder (Shawn Overholt), Mary Elizabeth Barrett (Medical Examiner), Joseph Gilbert (Manager), Porter Fowler (Older Man), Louise Claps (Older Woman), Kelly Lester (Woman), Zach Hanks (Guy), Nicole Stuart (Reporter), Michael Chandler (Reporter #2), Ruby Campbell (Reporter #3), Karen Fatta (Operator), Jason Delane (Philly Agent), Cory Tucker (Agent), James Aidan (Digger), Danny Barfield (Security Guard)
• Written By: Dan Dworkin & Jay Beattie
• Directed By: Glenn Kershaw

• Guest Starring: Nicholas Brendon (Kevin Lynch), Michael Shamus Wiles (Chester Hardwick), Nicholle Tom (Connie Galen), Dennis Christopher (Assistant Warden Merriman), E.J. Callahan (Landon), David Tom (Georgie Galen)
• Co-Starring: John Gloria (Detective Willis), Jessica Raskin (Alicia Galen), Big LeRoy Mobley (Bull), Christopher Heltai (Strip Club Customer), Matt Cates (Clown - Joe), Tim Trobec (Guard), Rando Thomas (Makeout Man), Natalie Dye (Connie Galen - 6 Years), Reese Fritch (Georgie Galen - 5 years), Clara Bommelje (Alicia Galen - 3 years)
• Written By: Edward Allen Bernero
• Directed By: Edward Allen Bernero

• Guest Starring: Paul Schulze (Ronnie Baleman), Jennifer Aspen (Laurie Ann Morris), Renée O'Connor (Pam Baleman), Scott Michael Campbell (Peter Redding), Blake Robbins (Jonathan Morris), Myk Watford (Curtis Fackler)
• Co-Starring: Zakareth Ruben (Beth Smoler), Rod Britt (Coroner), Brynn Horrocks (Woman #1), Craig Patton (Man #1), Brandon Ford Green (Stuart Sankler), Leslie Fleming-Mitchell (Smoker), Susan Hull (Woman #2), Tim Cummings (Man #2)
• Written By: Michael Udesky
• Directed By: Felix Alcala

• Guest Starring: Cody Kasch (Owen Savage), Chris Mulkey (Sheriff Britt Hallum), Lindsey Haun (Jordan Norris), Tim deZarn (Paul Barter), Alexandra Krosney (Eileen Bechtold), Tracey Walter (Ike Stratman), Michael Ironside (John)
• Co-Starring: Boo Arnold (Deputy Bart Lawford), Kym Jackson (Sarah Letts), Matthew Kimbrough (Deputy Lou Savage), Rhino Michaels (Rod Norris), Nicholas Roth (Danny Panzer), Devin Crittenden (Chad Heyman), Nicholas Alexander (Gavin Pressman)
• Written By: Andrew Wilder
• Directed By: Bobby Roth

• Guest Starring: Nicholas Brendon (Kevin Lynch), Josh Stewart (Detective William Montagne, Jr.), Tia Texada (Detective Tina Lopez), Michael Graziadei (Steven), Wendy Hoopes (Sarah Fitzgerald), David Monahan (Cowboy Hat Guy), James Martin Kelly (David Fitzgerald)
• Co-Starring: Michael Francis Cardelle (Bus Boy), Bruno Bruni (Hitchhiker), Jacqueline Wright (Hostel Manager), Jeryl Prescott Sales (Medical Examiner), Kara Revel (Layla), Douglas Barcellos (Carlos), Tom Sean Foley (Coordinator), Adrian Quinonez (Bartender #1), Spencer Hill (Bartender #2), Francesco Cura (Bar Patron), Billy Snow (Cards Kid)
• Written By: Andi Bushell
• Directed By: John Gallagher

• Guest Starring: Bonnie Root (Keri Derzmond), Jeffrey Pierce (Ryan Scott), Brad Beyer (Detective Steve Berry), Scott Lowell (Mike Hicks), Barbara Eve Harris (DA Eve Alexander), Mary-Margaret Humes (Audrey Henson)
• Co-Starring: Aviva (Sarah Henson), Victor Z. Isaac (Nathan Henson), Julie Sanford (Nancy Ferguson), Brian Appel (Agent Anderson), Angel Parker (Cashier), Guy Nardulli (Undercover Cop), Kosha Patel (Clerk)
• Written By: Debra J. Fisher & Erica Messer
• Directed By: Guy Norman Bee

• Guest Starring: Steven Culp (Lester Serling), Amy Carlson (Cece), Eric Lange (Brian Matloff), James Eckhouse (Mr. Corbett)
• Co-Starring: Anne Betancourt (Nina Moore), Roxana Brusso (Lidia), James Sharpe (Detective Jarvis), F. William Parker (Judge), Beau Dremann (Sergeant), Loreni Delgado (Technician), Dick Herlan (Husband), Bob Gebert (Doctor), Sarah MacKay (Nurse), John Pirruccello (Resident Jogger), Jenny Powers (Woman), Jon Barton (SWAT Officer)
• Written By: Dan Dworkin & Jay Beattie
• Directed By: Steve Boyum

• Guest Starring: Sienna Guillory (Kate Joyner), Josh Stewart (Detective William LaMontagne, Jr.), Erik Palladino (Detective Cooper), Jack McGee (Detective Brustin), Moe Daniels (Lisa Bartleby)
• Co-Starring: Joaquin Perles (Tom), Amie Farrell (Shelly), Barry Pearl (Man), Jake Eberle (Cop), Patrick Cupo (Cop #2), Tiffany Coty (FBI Agent)
• Written By: Chris Mundy
• Directed By: Glenn Kershaw