| Anson Mount ... Captain Christopher Pike |
| Ethan Peck ... Science Officer Spock |
| Jess Bush ... Nurse Christine Chapel |
| Christina Chong ... Lieutenant La'an Noonien-Singh |
| Celia Rose Gooding ... Cadet Nyota Uhura |
| Melissa Navia ... Lieutenant Erica Ortegas |
| Babs Olusanmokun ... Doctor Joseph M'Benga |
| Martin Quinn ... Lieutenant Montgomery Scott |
| Rebecca Romijn ... Commander Una Chin-Riley / Number One |
