• Guest Starring: Jim Beaver (Bobby Singer), Genevieve Cortese (Kristy / Ruby), Misha Collins (Castiel), Traci Dinwiddie (Pamela Barnes)
• Co-Starring: Scott Parsons (Demon Customer), Jen Halley (Demon Waitress), Marc Gaudet (Demon Cook)
• Written By: Eric Kripke
• Directed By: Kim Manners

• Guest Starring: Jim Beaver (Bobby Singer), Genevieve Cortese (Kristy / Ruby), Misha Collins (Castiel), Nicki Aycox (Meg), Charles Malik Whitfield (Special Agent Hendricksen), Chris Gauthier (Ronald Resnick)
• Co-Starring: Audra Ricketts (Olivia), Daniel Arnold (Ghostly Man), Eve Casha (Ghost Girl), Lara Casha (Ghost Girl), Krista Mitchell ()
• Written By: Sera Gamble
• Directed By: Phil Sgriccia

• Guest Starring: Mitch Pileggi (Samuel Campbell), Misha Collins (Castiel), Genevieve Cortese (Ruby), Matthew Cohen (Young John Winchester), Amy Gumenick (Young Mary Winchester), Allison Hossack (Deanna Campbell)
• Co-Starring: Christopher MacCabe (Yellow-Eyed Demon), Ken Camroux-Taylor (Mr. D), Troy Anthony Young (Diner Owner), Andy Nez (Daniel Elkins), Mark McConchie (Car Salesman), Nadine Wright (Beth Whitshire), Max Lloyd-Jones (Charles Whitshire), Viviana Dal Cengio (Liddy Walsh), Robert Dayton (Dr. Brown)
• Written By: Jeremy Carver
• Directed By: Steve Boyum

• Guest Starring: Genevieve Cortese (Ruby), Dameon Clarke (Jack Montgomery), Joanne Kelly (Michelle Montgomery), Ron Lea (Travis)
• Co-Starring: Craig Stanghetta (Bartender), Angelique Naude (Girl in Bar), Colby Wilson (Guy in Bar), Marcus Hondro (Captive Demon)
• Written By: Cathryn Humphris
• Directed By: Kim Manners

• Guest Starring: Todd Stashwick (Dracula / Shapeshifter), Melinda Sward (Jamie), Holly E. Dignard (Lucy), Michael Eklund (Ed Brewer)
• Co-Starring: Garry Chalk (Sheriff), Todd Scott (Security Guard), Carmen Lavigne (Anne Marie), Geoff Redknap (), Jason Poulsen (Rick Deacon), John Stewart (Pizza Delivery Guy), Giacomo Baessato ()
• Written By: Ben Edlund
• Directed By: Robert Singer

• Guest Starring: Jim Beaver (Bobby Singer), Sierra McCormick (Lilith), Jack Conley (Sheriff Al Britton), Stephen DuVall (John Garland), David Mattey (Luther Garland)
• Co-Starring: Jerry Wasserman (Coroner), Darcy Cadman (Deputy Linus), Michael Roberds (Mark Hutchens), Brady Schlecker (Frank O'Brien), Jessica Erwin (), Darren Daurie (), Wade Fennig ()
• Written By: Andrew Dabb & Daniel Loflin
• Directed By: Phil Sgriccia

• Guest Starring: Robert Wisdom (Uriel), Misha Collins (Castiel), Don McManus (Don Harding), Ashley Benson (Tracy Davis)
• Co-Starring: Kirsten Robek (Mrs. Wallace), Jean-Luc Bilodeau (Justin), Luisa D'Oliveira (Jenny), David Ingram (Luke Wallace), Alex Robertson ()
• Written By: Julie Siege
• Directed By: Charles Beeson

• Guest Starring: Anita Brown (Hope Lynn Casey)
• And: Ted Raimi (Wesley Mondale)
• Co-Starring: Chang Tseng (Chinese Waiter), Nicole Leduc (Audrey Elmer), Barbara Kottmeier (Candace Armstrong), Calum Worthy (Invisible Peeping Tom / Denny), Chad Krowchuk (Cheerful Waiter), Ryan Grantham (Todd), Michael Teigen (Police Officer), Sean Devine (Hunter), Noel Johansen (), Cainan Wiebe (Bully #1), Talon Dunbar (Bully #2), Evan Muirhead (Bully #3), Chris Peake (), Jessica Olafsen (Blonde in Shower)
• Teleplay By: Ben Edlund
• Story By: Ben Edlund & Lou Bollo
• Directed By: Robert Singer

• Guest Starring: Robert Wisdom (Uriel), Genevieve Cortese (Ruby), Misha Collins (Castiel), Julie McNiven (Anna Milton), Mark Rolston (Alastair), Gwynyth Walsh (Anna's Doctor)
• Co-Starring: Anna Williams (Ruby's Host Body #1), Drew Nelson (Crossroads Demon), Dave Collette (Demon Orderly), Shawn Hall (Pool Player), Samantha Page (Little Girl), Michelle Hewitt Williams (Maid), Anthony Harrison (Captive Demon), Glenn Ennis (Lilith's Demon #1), Mark Ferns (Lilith's Demon #2)
• Written By: Sera Gamble
• Directed By: Charles Beeson

• Guest Starring: Robert Wisdom (Uriel), Genevieve Cortese (Ruby), Misha Collins (Castiel), Julie McNiven (Anna Milton), Mark Rolston (Alastair), Traci Dinwiddie (Pamela Barnes)
• Teleplay By: Eric Kripke
• Story By: Trevor Sands
• Directed By: J. Miller Tobin

• Guest Starring: Helen Slater (Susan Carter), David Newsom (Brian Carter), Bradley Stryker (Uncle Ted), Alexa Nikolas (Kate Carter), Dylan Minnette (Danny Carter), Mandy Playdon (The Girl)
• Co-Starring: Gerry Rousseau (Bill Gibson), Mark Wynn (The Boy), Karin Konoval (Mrs. Curry)
• Written By: Jeremy Carver
• Directed By: Phil Sgriccia

• Guest Starring: Barry Bostwick (Jay), Luke Camilleri (Jeb Dexter), Genevieve Cortese (Ruby), Richard Libertini (Vernon), John Rubinstein (Charlie), Michael Rubenstein (Young Charlie)
• Co-Starring: Alex Zahara (Patrick Vance), Anber Lewis (Waitress), Ecstasia Sanders (Vance's Assistant), Jordan Becker (Doorman), Chris Burns (Chief)
• Written By: Julie Siege
• Directed By: Robert Singer

• Guest Starring: Colin Ford (Young Sam), Brock Kelly (Young Dean), Candice Accola (Amanda), Chad Willett (Mr. Wyatt)
• Co-Starring: Tim Henry (Dirk MacGregor, Sr.), Cainan Wiebe (Barry Cook), Casey Dubois (Dirk MacGregor, Jr.), Adam MacDougall (), Jenna Romanin (), Eileen Barrett (Young Dean's Teacher), Hayley Saulnier (), Reilly Dolman (), Adam Kennedy (), Marie Avgeropoulos (Taylor), Merritt Patterson (Cheerleader), Maggie Ma (Jennifer Tanaka), Jermaine Peralta (), Dan Joffre (Coach), Doug Abrahams (Eddie)
• Written By: Andrew Dabb & Daniel Loflin
• Directed By: Adam Kane

• Guest Starring: Jim Beaver (Bobby Singer), Genevieve Cortese (Ruby), Maite Schwartz (Cara Roberts), Jim Parrack (Agent Nick Munroe), Mark Hildreth (Adam Benson)
• Co-Starring: Tosha Doiron (Vicky Benson), Lawrence Haegert (Lenny Bristol), Moneca Delain (Belle), Fulvio Cecere (Honey Wagon Owner), Brandi Alexander (Stripper), Chris Baker (Siren)
• Written By: Cathryn Humphris
• Directed By: Charles Beeson

• Guest Starring: Misha Collins (Castiel), Traci Dinwiddie (Pamela Barnes), Christopher Heyerdahl (Alastair), Lindsey McKeon (Tessa), Alexander Gould (Cole Griffiths)
• Co-Starring: Mike Dopud (Jim Jenkins), Andrew Wheeler (Mugger), Viv Leacock (Jim's Friend), Maya Massar (Mara Griffiths), Gabriel Carter (), John Burnside (Jacob), Phillip Mitchell (), Kristian Haas (), Chris McNally ()
• Written By: Jeremy Carver
• Directed By: Steve Boyum
• Note: We dedicate the entire season to Kim Manners. We miss you, Kim.

• Guest Starring: Robert Wisdom (Uriel), Misha Collins (Castiel), Genevieve Cortese (Ruby), Julie McNiven (Anna Milton), Christopher Heyerdahl (Alastair)
• Co-Starring: Brent Woolsey (), Crystell Hendricks ()
• Written By: Ben Edlund
• Directed By: Mike Rohl

• Guest Starring: Kurt Fuller (Mr. Adler), Jack Plotnick (Ian), A.J. Buckley (Ed Zeddemore), Travis Wester (Harry Spengler)
• Co-Starring: Richard Side (Paul Dunbar), John Hainsworth (), David Milchard (Dean's Co-Worker), Steve Elliott (), Brian McCaig (Security Guard)
• Written By: Sera Gamble
• Directed By: James L. Conway

• Guest Starring: Misha Collins (Castiel), Kurt Fuller (Zachariah), Katherine Boecher (Lilith), Rob Benedict (Carver Edlund / Chuck Shurley), Keegan Connor Tracy (Publisher)
• Co-Starring: Michael P. Northey (Comic Book Store Owner), Mike Klemak (Trooper), Terri O'Neill (Waitress), Megan Leitch (Woman Driver), Reilly Kiff (Girl)
• Teleplay By: Julie Siege
• Story By: Julie Siege & Nancy Weiner
• Directed By: Mike Rohl

• Guest Starring: Jake Abel (Adam Milligan), Dedee Pfeiffer (Kate Milligan)
• Co-Starring: Heather Feeney (Lisa Barton), Michael Puttnam (Cemetary Director), Eby Luking (Denise)
• Written By: Andrew Dabb & Daniel Loflin
• Directed By: Phil Sgriccia

• Guest Starring: Misha Collins (Castiel), Jim Beaver (Bobby Singer), Julie McNiven (Anna), Wynn Everett (Amelia), Sydney Imbeau (Claire)
• Co-Starring: Aaron Pearl (Jack), Linnea Sharples (Lisa)
• Written By: Jeremy Carver
• Directed By: Charles Beeson

• Guest Starring: Jim Beaver (Bobby Singer), Genevieve Cortese (Ruby), Misha Collins (Castiel), Julie McNiven (Anna), Christopher Heyerdahl (Alastair), Colin Ford (Young Sam), Samantha Smith (Mary Winchester)
• Co-Starring: Juliana Wimbles (Demon Nurse), Joey Bothwell (Nurse)
• Written By: Sera Gamble
• Directed By: Robert Singer

• Guest Starring: Jim Beaver (Bobby Singer), Genevieve Cortese (Ruby), Misha Collins (Castiel), Kurt Fuller (Zachariah), Katherine Boecher (Lilith), Rob Benedict (Chuck Shurley), Rob LaBelle (Father Lehne), Juliana Wimbles (Cindy McClellan)
• Co-Starring: Darren Dolynski (), Artine Brown (Night Watchman), Kirsten Kilburn ()
• Written By: Eric Kripke
• Directed By: Eric Kripke