Guest Starring: Camille Mitchell (Sheriff Nancy Adams), William B. Davis (Mayor William Tate), Tom Heaton (Dexter), Tim Henry (Private Investigator Mason)
Co-Starring: John Mann (Young Dexter), Kendall Cross (Jessica Kent), Michael Karl Richards (Sheriff Billy Tate), Peter Benson (Lachlan Luthor), Dean Wray (Hiram Kent)
Written By: Kelly Souders & Brian Peterson
Directed By: Marita Grabiak
Ep: 51
Magnetic
Guest Starring: Kevin Zegers (Seth Nelson), Tim Henry (Private Investigator Mason), Camille Mitchell (Sheriff Nancy Adams)
Co-Starring: Steven Cree Molison (Trucker), Rimple Sumer (Wendy Schwiebe), James Hutson (MRI Doctor), Scott Swanson (Doctor), Doug Chapman (Deputy)
Written By: Holly Harold
Directed By: David Jackson
Ep: 52
Shattered
Special Guest Star: Patrick Bergin (Morgan Edge)
Guest Starring: Lorena Gale (Dr. Claire Foster)
Co-Starring: Kwesi Ameyaw (Darius), Michael Benyaer (Assassin), Michael Daingerfield (Security Guard), Angelo Renai (Surgeon), Donald Fong (Factory Owner), Darryl Scheelar (Jameson)
Written By: Kenneth Biller
Directed By: Kenneth Biller
Ep: 53
Asylum
Guest Starring: Ian Somerhalder (Adam Knight), Jonathan Taylor Thomas (Ian Randall), Jesse Metcalfe (Van McNulty), Lorena Gale (Dr. Claire Foster), Shawn Ashmore (Eric Summers)
Co-Starring: Ron Selmour (Connelly), Elias Toufexis (Luke), Paul Moniz De Sa (Orderly), Jason Benson (), Gina Doty (Physical Therapist), R. David Stephens (Doctor), Jennifer Kitchen (), Leanna Nash (), Julius Chapple ()
Co-Starring: William MacDonald (Masterson), French Tickner (Jewlery Store Owner), Ecstasia Sanders (), Lisa Marie Caruk ()
Written By: Ken Horton
Directed By: Thomas J. Wright
Ep: 55
Delete
Guest Starring: Ian Somerhalder (Adam Knight), Camille Mitchell (Sheriff Nancy Adams), Missy Peregrym (Molly Griggs), Martin Cummins (Dr. Garner)
Co-Starring: Jim Thorburn (Max Taylor), Suzanne Ristic (Max's Secretary), Chris Gauthier (LuthorCorp Technician), Cornell Turner (Security Guard)
Written By: Kelly Souders & Brian Peterson
Directed By: Pat Williams
Ep: 56
Hereafter
Guest Starring: Ian Somerhalder (Adam Knight), Joseph Cross (Jordan Cross), Camille Mitchell (Sheriff Nancy Adams), Greg Kean (Coach Altman)
Co-Starring: Meghan Ory (Megan), Shaun Johnston (Mr. Cross), Louise Grant (Elderly Lana)
Written By: Mark Verheiden & Drew Z. Greenberg
Directed By: Greg Beeman & James Marshall
Ep: 57
Velocity
Guest Starring: Ian Somerhalder (Adam Knight), Camille Mitchell (Sheriff Nancy Adams), Francoise Yip (Dr. Lia Teng), Ryan Merriman (Jason Dante)
Co-Starring: Moneca Delain (Mara), Colin Corrigan (Mechanic), Chris Kalhoon ()
Written By: Todd Slavkin & Darren Swimmer
Directed By: Jeannot Szwarc
Ep: 58
Obsession
Guest Starring: Ian Somerhalder (Adam Knight), Sarah Carter (Alicia Baker), Lynda Boyd (Mrs. Baker), Paul Perri (Mr. Baker), Francoise Yip (Dr. Lia Teng), Camille Mitchell (Sheriff Nancy Adams)
Co-Starring: Kate Robbins (Teacher)
Written By: Holly Harold
Directed By: Holly Harold
Ep: 59
Resurrection
Guest Starring: Francoise Yip (Dr. Lia Teng), Camille Mitchell (Sheriff Nancy Adams), Jerry Wasserman (Dr. Yaeger), James Kirk (Garrett Davis), Tahmoh Penikett (Vincent Davis)
Co-Starring: Julian Christopher (Dr. MacIntyre), Sandra Ferens (Morgue Doctor), Jonathan Ndukwe (), Bruce Harwood (Ben Powell), Nigel Vonas ()
Written By: Todd Slavkin & Darren Swimmer
Directed By: Terrence O'Hara
Ep: 60
Crisis
Guest Starring: Ian Somerhalder (Adam Knight), Gary Hudson (FBI Agent Frank Loder), Francoise Yip (Dr. Lia Teng), Terry Chen (Detective Paul Kabe), Camille Mitchell (Sheriff Nancy Adams)
Co-Starring: Aaron Pearl (Glenn Burton), Johannah Newmarch (Gwen Burton), Deryl Hayes (Second Detective), Cedric De Souza (Dr. Burgeon), Renee Janssen ()
Written By: Kelly Souders & Brian Peterson
Directed By: Kenneth Biller
Ep: 61
Legacy
Special Appearance By: Christopher Reeve (Dr. Virgil Swann)
Guest Starring: Gary Hudson (FBI Agent Frank Loder)
Co-Starring: Timothy Paul Perez (FBI Agent Tobin), Daniel Bacon (FBI Agent), John Shaw (Scientist)
Written By: Jeph Loeb
Directed By: Greg Beeman
Ep: 62
Truth
Guest Starring: Gillian Barber (Mrs. Taylor)
Co-Starring: Mark Houghton (Lab Technician), Andrew Francis (), Don Thompson (), Linden Banks (Jonah Doyle), Samantha Banton (Rebecca), Ryan Steele (Doug), Christie Laing (Mindy), Victoria Anderson (Hospital Receptionist), Ivan Cermak (Intern)
Written By: Drew Z. Greenberg
Directed By: James Marshall
Ep: 63
Memoria
Special Guest Star: Terence Stamp (The Voice of Jor-El)
Guest Starring: Wayne Dalglish (Young Lex), Martin Cummins (Dr. Garner), Alisen Down (Lillian Luthor)
Co-Starring: Andrew Airlie (Mr. Woodward), Matthew Harrison (Tech), Elizabeth Thai (Sommerholt Receptionist), Michael-Ann Connor (Cute Receptionist), Kendall Cross (Voice of Lara)
Written By: Alfred Gough & Miles Millar
Directed By: Miles Millar
Ep: 64
Talisman
Guest Starring: Gordon Tootoosis (Professor Joseph Willowbrook), Nathaniel Arcand (Jeremiah Holdsclaw)
Co-Starring: Teryl Rothery (Real Estate Agent)
Written By: Kenneth Biller
Directed By: John Schneider
Ep: 65
Forsaken
Guest Starring: Neil Flynn (Pete Dinsmore), Gary Hudson (FBI Agent Frank Loder), Amber Rothwell (Emily Dinsmore)
Co-Starring: Scott Bellis (Monitoring Technician), Ryan Booth (Worker)
Written By: Kelly Souders & Brian Peterson
Directed By: Terrence O'Hara
Ep: 66
Covenant
Special Guest Star: Terence Stamp (The Voice of Jor-El)
Guest Starring: Adrianne Palicki (Kara), Gary Hudson (FBI Agent Frank Loder), Robert Wisden (Gabe Sullivan)
Co-Starring: Sarah Deakins (Trial Reporter), Daniel Bacon (FBI Agent), Brandon McLaren (Delivery Man), Rick Faraci (Prison Barber)