Co-Starring: Ona Grauer (Dr. Gabrielle Vaughan), Dan Joffre (Admissions Nurse), Rekha Sharma (Dr. Harden), Mina E. Mina (), Bill Meilen (), Ian Robison (), Viv Leacock (), Alexander Kalugin (Seer), Helena Yea ()
Written By: Alfred Gough & Miles Millar
Directed By: Greg Beeman
Ep: 68
Gone
Special Guest Star: Erica Durance (Lois Lane)
Guest Starring: Michael Ironside (General Sam Lane), Robert Wisden (Gabe Sullivan)
Co-Starring: James Bell (), Colin Lawrence (), James Michalopoulos (), Michael Jonsson ()
Written By: Kelly Souders & Brian Peterson
Directed By: James Marshall
Ep: 69
Facade
Special Guest Star: Erica Durance (Lois Lane)
Guest Starring: Brianna Lynn Brown (Abigail Fine), Eric Johnson (Whitney Fordman), Julianne Christie (Dr. Elaine Fine), Michael Ironside (General Sam Lane)
Co-Starring: Lee Rumohr (Brett Anderson), Rob Freeman (), Jared Keeso (Nate)
Written By: Holly Harold
Directed By: Pat Williams
Ep: 70
Devoted
Special Guest Star: Erica Durance (Lois Lane)
Guest Starring: Amanda Walsh (Mandy)
Co-Starring: Chelan Simmons (), Lisa Marie Caruk (), Moneca Delain (Mara), Jared Keeso (Nate), Graham Kosakoski (Dan Cormay), Colby Wilson (), Graham Young ()
Written By: Luke Schelhaas
Directed By: David Carson
Note: In Loving Memory Of Christopher Reeve He made us believe a man could fly.
Ep: 71
Run
Guest Starring: Kyle Gallner (Bart Allen), Benjamin Ratner (Hanison)
Guest Starring: Jonathan Bennett (Kevin Grady), Tom Butler (Lawrence Grady), Camille Mitchell (Sheriff Nancy Adams)
Co-Starring: Heather Doerksen (Receptionist), Ryan King (Dylan Grady)
Written By: Kelly Souders & Brian Peterson
Directed By: Jeannot Szwarc
Ep: 86
Ageless
Special Appearance By: Jane Seymour (Genevieve Teague)
Guest Starring: Jeff Ballard (Evan at 14 Years), Colin Ford (Evan at 7 Years), Camille Mitchell (Sheriff Nancy Adams)
Co-Starring: Matt Ellis (Tanner Sutherland), Pascale Hutton (Susan Gallagher), Owen Stewart (Baby Evan), Elizabeth Stewart (Baby Evan), John Shaw (LuthorCorp Scientist), Frank C. Turner (Mechanic), Michael Kersch (), Marshall Kaplan (Lex's Aide)
Written By: Steven S. DeKnight
Directed By: Steven S. DeKnight
Ep: 87
Forever
Special Guest Star: Erica Durance (Lois Lane)
Special Appearance By: Jane Seymour (Genevieve Teague)
Guest Starring: Steven Grayhm (Brendan Nash)
Co-Starring: Fiona Scott (Haley Timmonds), Chad Krowchuk (Wendel), Stephanie Nudd (), Keira Kabatow (), Michaela Mann (), Veena Sood (Schoolteacher)
Written By: Kelly Souders & Brian Peterson
Directed By: James Marshall
Ep: 88
Commencement
Special Guest Stars: Erica Durance (Lois Lane), Terence Stamp (The Voice of Jor-El)
Special Appearance By: Jane Seymour (Genevieve Teague)
Co-Starring: Anthony Harrison (), David Orth (), Tom Pickett (), Craig Veroni (), Robert Gauvin (), Jeremy Jones (Young Father), Kwes Thompson (), Brayden Anderson ()