Co-Starring: Curtis Caravaggio (Wingate Owner), Noah Danby (Club Bouncer), Kristin Coutu (), Sarah Mutch (), Katharine Horsman (), Brandi Alexander (), Tara Wilson (), Natalie Morris ()
Written By: Kelly Souders & Brian Peterson
Directed By: Jeannot Szwarc
Ep: 95
Splinter
Special Guest Star: James Marsters (Dr. Milton Fine)
Written By: Steven S. DeKnight
Directed By: James Marshall
Ep: 96
Solitude
Special Guest Stars: James Marsters (Professor Milton Fine), Terence Stamp (The Voice of Jor-El)
Co-Starring: Aleks Holtz (Gate Guard), Benita Ha (Dr. Asuka)
Featuring: Bud the Dog (Shelby)
Written By: Todd Slavkin & Darren Swimmer
Directed By: Paul Shapiro
Ep: 97
Lexmas
Guest Starring: Kenneth Welsh (Drunk Santa), Alisen Down (Lillian Luthor), Adrian Holmes (Griff)
Co-Starring: Jerry Wasserman (Dr. Scanlon), Chelah Horsdal (Dr. McCann), Adam J. Harrington (Dr. Litvack), Cassandra Sawtell (Little Girl), Elfina Luk (Female Gangbanger), Jorgito Vargas, Jr. (Male Gangbanger), Nico Ghisi (Alexander Luthor), Brad Loree ()
Featuring: Bud the Dog (Shelby)
Written By: Holly Harold
Directed By: Rick Rosenthal
Ep: 98
Fanatic
Guest Starring: Annie Burgstede (Samantha Drake), Adrian Holmes (Griff)
Co-Starring: Dean McKenzie (Campaign Manager), David Richmond Peck (March Sosnick), Sage Brocklebank (James), Miles Meadows (Doug)
Featuring: Bud the Dog (Shelby)
Written By: Wendy Mericle
Directed By: Michael Rohl
Ep: 99
Lockdown
Guest Starring: Kevin Daniels (Gregory R. Flynn), Camille Mitchell (Sheriff Nancy Adams), Sarah Lind (Deputy Harris)
Co-Starring: Michael Ryan (Psychiatrist), Chris Shields (Courier), David MacInnis (EMT), Dean McKenzie (Campaign Manager), Marc-Anthony Massiah (Security Guard), Steve Archer (Deputy)
Featuring: Bud the Dog (Shelby)
Written By: Steven S. DeKnight
Directed By: Peter Ellis
Ep: 100
Reckoning
Special Guest Star: Terence Stamp (The Voice of Jor-El)
Guest Starring: Marrett Green (TV News Announcer), Kimani Ray Smith (), Vanesa Tomasino (Secretary), Preston Cook (Angry Young Suit), Chris Shields (Courier)
Co-Starring: Christie Laing (Katherine), Mackenzie Gray (Dr. Alistair Kreig), Rick Tae (Dr. Hong), Adrian Hughes (Blackmailer)
Written By: Caroline Dries
Directed By: Glen Winter
Ep: 104
Hypnotic
Special Guest Star: James Marsters (Professor Milton Fine)
Guest Starring: Nichole Hiltz (Simone)
Co-Starring: Linden Banks (), Aaron Craven (Scientist), Parker Jay (Aide), Alejandro Chavarria (Honduran Boy), Sina Najafi ()
Written By: Todd Slavkin & Darren Swimmer
Directed By: Michael Rohl
Note: In Memory of Dana Reeve (1961 - 2006)
Ep: 105
Void
Guest Starring: Patrick Currie (Lance), Alisen Down (Lillian Luthor)
Co-Starring: Michaela Mann (Ally), Wendy Chmelauskas (Laura Lang), Ben Odberg (Lewis Lang), Brenda M. Crichlow (Press Conference Reporter), Alistair Abell (Professor), Alejandro Chavarria (Honduran Boy), Luis Javier (Press Conference Reporter), Shannon Baker (), Shauna Baker ()
Written By: Holly Harold
Directed By: Jeannot Szwarc
Ep: 106
Fragile
Guest Starring: Callum Keith Rennie (Tyler McKnight), Emily Hirst (Maddie Van Horn)
Co-Starring: Anne Marie DeLuise (Naomi Van Horn), Maxine Miller (Mrs. McKnight), James Upton (Frank Colbert), Steve Archer (Deputy), Panou (Phillippine Envoy), Lee Kim (Asian Envoy)